In my experience, when moving from IEM to IEM, there is a period of adjustment as you become more familiar with the new sound signature. This is especially visible when moving from warmer to more analytical IEMs.
I tested my is IE8s, which had over 600 hours on them against a friends who had bought his new through my Sony S639 (good quality portable source). I honestly could not tell any difference between the two.
Having said that, I was sure there was a burn in effect when I first bought them, but I guess this is due to placebo effect and your brain adjusting to the sound.
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